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KMID : 1007520140230030931
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Food Science and Biotechnology
2014 Volume.23 No. 3 p.931 ~ p.935
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Xanthigen Attenuates High-fat Diet-induced Obesity through Down-regulation of PPARγ and Activation of the AMPK Pathway
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Choi Kyeong-Mi
Jeon Young-Soo
Kim Won-Kyun
Lee An-na
Kim Yong-Gil
Lee Ju-Hyun
Kang Young-Eun
Jung Jae-Chul
Lee Jeong-Rai
Min Bok-Kee
Kwon Suk-Hyung
Davis Barbara
Lee Mi-Kyeong
Yoo Hwan-Soo
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Abstract
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Xanthigen, a mixture of brown seaweed and pomegranate seed extracts, has weight loss properties and lipid-lowering effects in mice and humans. This study elucidated the Xanthigen mechanism of an anti-obesity activity in high-fat diet (HFD)-fed mice. Xanthigen decreased expression of peroxisome proliferator-activated receptor γ (PPARγ) in the adipose tissue of HFD-fed mice. The serum leptin level and the adipose tissue leptin expression in mice fed HFD plus Xanthigen were significantly decreased, compared to HFD-fed mice. Phosphorylation of AMPactivated protein kinase (AMPK) α and β and acetyl-CoA carboxylase (ACC) in the adipose tissue of HFD plus Xanthigen-fed mice was elevated, and HMG-CoA reductase (HMGCR) expression was decreased. Xanthigen may have an anti-obesity activity by down-regulation of PPARγ and activation of the AMPK pathway.
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KEYWORD
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Xanthigen, PPARγ, AMPK, leptin, obesity
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